H&AD S.r.l. is partner with

    NUTRAMED S.C.A.R.L.

NUTRAMED


RESEARCH PARTNERS:
IRRCCS SAN RAFFAELE S.p.A.
UNICZ MAGNA GRECIA
C.I.R.M.
S.B.M. S.r.l.
MASSA SPIN OFF C.N.R.
SALUS S.P.A.
ALPIFLOR S.r.l.
SERIS S.r.l.
ITOP S.p.A.
MED SISTEM S.r.l.
VILLA DEI GERANI GESTIONE S.r.l.

OPEN CALLS:

CALLS FOR A SHORT LIST OF EXPERTS AND SUPPLIERS OF GOODS AND SERVICES FINALIZED TO THE REALIZATION OF RESEARCH AND DEVELOPMENT PROJECTS (Ref. Nutramed project) .—> CALL FOR EXPERTS AND SUPPLIERS 


r&p

The protective effect of bergamot oil extract on lecitine-like oxyLDL receptor-1 expression in balloon injury-related neointima formation.
Mollace V, Ragusa S, Sacco I, Muscoli C, Sculco F, Visalli V, Palma E, Muscoli S, Mondello L, Dugo P, Rotiroti D, Romeo F.
J Cardiovasc Pharmacol Ther. 2008 Jun;13(2):120-9.

Hypolipidemic Effects of Citrus bergamia Risso et Poiteau Juice in Rats Fed a Hypercholesterolemic Diet
Miceli N, Mondello MR, Monforte MT, Sdrafkakis V, Dugo P, Crupi ML, Taviano MF, De Pasquale R, Trovato A J Agric Food Chem. 2007 Dec 26;55(26):10671-7. Epub 2007 Nov 27.

Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. (Prodotto utilizzato: BPF® di H&AD Srl).
Mollace V, Sacco I, Janda E, Malara C, Ventrice D, Colica C, Visalli V, Muscoli S, Ragusa S, Muscoli C, Rotiroti D, Romeo F.
Fitoterapia. 2011 Apr;82(3):309-16.

Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. (Prodotto utilizzato: BPF® di H&AD Srl).
Gliozzi M, Walker R, Muscoli S, Vitale C, Gratteri S, Carresi C, Musolino V, Russo V, Janda E, Ragusa S, Aloe A, Palma E, Muscoli C, Romeo F, Mollace V. Int J Cardiol. 2013 Dec 10;170(2):140-5

Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides.
Di Donna L, De Luca G, Mazzotti F, Napoli A, Salerno R, Taverna D, Sindona G. J Nat Prod. 2009 Jul;72(7):1352-4.

Mechanisms underlying the anti-tumoral effects of Citrus Bergamia juice.
Delle Monache S, Sanità P, Trapasso E, Ursino MR, Dugo P, Russo M, Ferlazzo N, Calapai G, Angelucci A, Navarra M. PLoS One. 2013 Apr 16;8-16.

The effect of bergamot-derived polyphenolic fraction on LDL small dense particles and non alcoholic fatty liver disease in patients with metabolic syndrome. (Prodotto utilizzato: BPF® di H&AD Srl)
Gliozzi M, Carresi C, Musolino V, Palma E, Muscoli C, Gratteri S, Muscianisi G, Janda E, Muscoli S, Romeo F, Walker R, Ehrlich J and Mollace V Advances in Biological Chemistry, 2014, 236-245

On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme.
Leopoldini M, Malaj N, Toscano M, Sindona G, Russo N.
J Agric Food Chem. 2010 Oct 13;58(19):10768-73.

Bergamot polyphenol fraction prevents non-alcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome. (Prodotto utilizzato: BPF® di H&AD Srl).
Maddalena Parafati, Antonella Lascala, Valeria Morittu, Francesca Trimboli, Antonia Rizzuto, Elvira Brunelli, Francesca Coscarelli, Nicola Costa, Emanuela Oliverio, Domenico Britti, Ciro Isidori, Vincenzo Mollace and Elzbieta Janda In Press

Bergamot Polyphenols: Pleiotropic Players in the Treatment of Metabolic Syndrome.
Gliozzi M,Walker R and Mollace V
J Metabolic Syndrome 2014, 2, 35-42

The use of bergamot-derived Polyphenol Fraction in Cardiometabolic Risk Prevention and its Possible Mechanisms of Action.
Walker R, Janda E and Mollace V Chp 84; pg 1085-1103,2014

Inhibition of intestinal and renal Na + glucose cotransporter by naringenin.
Li.J.M, Che.C.T, Lau.C.B, Leung.P.S, Cheng.C.H, (2006).
Int J Biochem Cell Biol 38: 985-995.

Antioxidant activity of citrus Limonoids, flavonoids and courmarins.
Yu.J, Wang.L, Walzem.R.L, Miller.E.G, Pike. L.M, Patil.B.S. (2005).
J. Agric Food Chem 53: 2009-2014.

Polyphenol antioxidant in citrus juices, in vitro and in vivo studies relevant to heart disease.
Vinson.J, Liang.X, Proch.J, Hontz.B, Dancel.J, Sandone.N. (2002).
Adv Exp Med Biol 505: 113-122.