Scale production of Bergamot derivatives

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bpf-logo BPF® Bergamot Polyphenolic Fraction

                   PATENTS:  IT  0001380456 – EP 2364158 – EP3415156 – PCT/IB2009/055060

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Research and clinical studies in collaboration with worldwide recognized Doctors.

H&AD  is partner with the Consortium Nutramed SCARL, IRCCS San Raffaele La Pisana in Rome, University Magna Graecia of Catanzaro (Department of Pharmaceutical Sciences), CIRM Milan, Farmaflor, Massa Spin Off,  CNR.

BPF helps to reduce total cholesterol
BPF helps to reduces Triglycerides
BPF helps to increase good cholesterol (HDL)
BPF helps to reduces blood sugar

The protective effect of bergamot oil extract on lecitine-like oxyLDL receptor-1 expression in balloon injury-related neointima formation.
Mollace V, Ragusa S, Sacco I, Muscoli C, Sculco F, Visalli V, Palma E, Muscoli S, Mondello L, Dugo P, Rotiroti D, Romeo F. J Cardiovasc Pharmacol Ther. 2008 Jun;13(2):120-9.

Hypolipidemic Effects of Citrus bergamia Risso et Poiteau Juice in Rats Fed a Hypercholesterolemic Diet
Miceli N, Mondello MR, Monforte MT, Sdrafkakis V, Dugo P, Crupi ML, Taviano MF, De Pasquale R, Trovato A J Agric Food Chem. 2007 Dec 26;55(26):10671-7. Epub 2007 Nov 27.

Herbal & Antioxidant Derivatives S.r.l. – Ricerca Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. (Prodotto utilizzato: BPF® di H&AD Srl).
Mollace V, Sacco I, Janda E, Malara C, Ventrice D, Colica C, Visalli V, Muscoli S, Ragusa S, Muscoli C, Rotiroti D, Romeo F. Fitoterapia. 2011 pr;82(3):309-16.

Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. (Prodotto utilizzato: BPF® di H&AD Srl).
Gliozzi M, Walker R, Muscoli S, Vitale C, Gratteri S, Carresi C, Musolino V, Russo V, Janda E, Ragusa S, Aloe A, Palma E, Muscoli C, Romeo F, Mollace V. Int J Cardiol. 2013 Dec 10;170(2):140-5

Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides.
Di Donna L, De Luca G, Mazzotti F, Napoli A, Salerno R, Taverna D, Sindona G. J Nat Prod. 2009 Jul;72(7):1352-4.

Mechanisms underlying the anti-tumoral effects of Citrus Bergamia juice.
Delle Monache S, Sanità P, Trapasso E, Ursino MR, Dugo P, Russo M, Ferlazzo N, Calapai G, Angelucci A, Navarra M. PLoS One. 2013 Apr 16;8-16.

The effect of bergamot-derived polyphenolic fraction on LDL small dense particles and non alcoholic fatty liver disease in patients with metabolic syndrome. (Prodotto utilizzato: BPF® di H&AD Srl)
Gliozzi M, Carresi C, Musolino V, Palma E, Muscoli C, Gratteri S, Muscianisi G, Janda E, Muscoli S, Romeo F, Walker R, Ehrlich J and Mollace V Advances in Biological Chemistry, 2014, 236-245

On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme. Leopoldini M, Malaj N, Toscano M, Sindona G, Russo N. J Agric Food Chem. 2010 Oct 13;58(19):10768-73.

Bergamot polyphenol fraction prevents non-alcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome. (Prodotto utilizzato: BPF® di H&AD Srl).
Maddalena Parafati, Antonella Lascala, Valeria Morittu, Francesca Trimboli, Antonia Rizzuto, Elvira Brunelli, Francesca Coscarelli, Nicola Costa, manuela Oliverio, Domenico Britti, Ciro Isidori, Vincenzo Mollace and Elzbieta Janda, In Press

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